Massive deletion inAZFb/b+cand azoospermia with Sertoli cell only and/or maturation arrest
نویسندگان
چکیده
منابع مشابه
AZF and DAZ gene copy-specific deletion analysis in maturation arrest and Sertoli cell-only syndrome.
Deletions of the AZFc region in Yq11.2, which include the DAZ gene family, are responsible for most cases of male infertility and were associated with severe oligozoospermia and also with a variable testicular pathology. To uncover the functional contribution of DAZ to human spermatogenesis, a DAZ gene copy-specific deletion analysis was previously established and showed that DAZ1/DAZ2 deletion...
متن کاملSertoli cell-only syndrome
Sertoli cell-only syndrome is defined by the complete absence of germ cells in testicular tissues and always results in male infertility. Germ cells give rise to next stages of spermatogenesis which is the process of sperm formation. They are normally attached to Sertoli cells forming together so called seminiferous tubules which form testicular tissue. If there are only Sertoli cells, then n...
متن کاملSertoli cell-only syndrome
Sertoli cell-only syndrome is defined by the complete absence of germ cells in testicular tissues and always results in male infertility. Germ cells give rise to next stages of spermatogenesis which is the process of sperm formation. They are normally attached to Sertoli cells forming together so called seminiferous tubules which form testicular tissue. If there are only Sertoli cells, then n...
متن کاملSertoli cell only syndrome.
Sertoli cell only syndrome was first described by Del Castillo et al. (1947). According to the original description it has been used when no spermatogenic cells have been seen in a testicular biopsy specimen. It is therefore unfortunate that the name of this syndrome has been misused in Human Reproduction in connection with cases where Sertoli cell only has been a diagnostic failure by a pathol...
متن کاملSertoli cell-only syndrome
Sertoli cell-only syndrome is defined by the complete absence of germ cells in testicular tissues and always results in male infertility. Germ cells give rise to next stages of spermatogenesis which is the process of sperm formation. They are normally attached to Sertoli cells forming together so called seminiferous tubules which form testicular tissue. If there are only Sertoli cells, then n...
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ژورنال
عنوان ژورنال: International Journal of Andrology
سال: 2008
ISSN: 0105-6263,1365-2605
DOI: 10.1111/j.1365-2605.2007.00808.x